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KMID : 0191120080230010083
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Journal of Korean Medical Science
2008 Volume.23 No. 1 p.83 ~ p.88
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Body Mass Index is Associated with USF1 Haplotype in Korean Premenopausal Women
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Lee Seong-Kyu
Lee Je-Chul
Kim Hyun-Jin
Park Kang-Seo
Kim Byung-Joon
Jo Young-Suk
Hyun Sung-Hee
Kim Soon-Ae
Baik Hang-Woon
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Abstract
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The upstream stimulatory factor 1 (USF1) gene has been shown to play an essential role as the cause of familial combined hyperlipidemia, and there are several association studies on the relationship between USF1 and metabolic disorders. In this study, we analyzed two single nucleotide polymorphisms in USF1 rs2073653 (306A>G) and rs2516840 (1748C>T) between the case (dyslipidemia or obesity) group and the control group in premenopausal females, postmenopausal females, and males among 275 Korean subjects. We observed a statistically significant difference in the GC haplotype between body mass index (BMI) > or =25 kg/m(2) and BMI <25 kg/m(2) groups in premenopausal females ( chi-square=4.23, p=0.04). It seems that the USF1 GC haplotype is associated with BMI in premenopausal Korean females.
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KEYWORD
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USF1, Polymorphism, Haplotypes, Body Mass Index
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